At the forefront of PDGF research
Dr. Lynch is the world’s leading authority on growth factors, specifically PDGF research and commercialization. He has over 120 patents and over 150 published papers. Additionally, there is a body of work spanning over 1,000 published articles evaluating PDGF.
Explore the decades-long body of research to discover Dr. Lynch’s unmatched contribution to the advancement, innovation, and proliferation of PDGF in medicine and cosmetics.
DISCLAIMER: The accompanying articles discuss approved and unapproved uses of recombinant human Platelet-Derived Growth Factor-BB (rhPDGF-BB or PDGF). Unapproved uses of PDGF have not been approved by the FDA, and the safety and effectiveness of PDGF for such unapproved uses have not been established. The articles are provided for informational and scientific discussion purposes only and does not constitute promotion of any unapproved product or use.
PDGF Reviews & Evidence Summaries
Published reviews of PDGF applications
Foundational PDGF Biology
Laboratory Research
- Kim MS et al. Comparative Study of Various Growth Factors and Cytokines on type I Collagen and Hyaluronan Production in Dermal Fibroblasts (2014)
- Bondesen S et al. Dermal fibroblasts have different extracellular matrix profiles induced by TGF-β, PDGF and IL-6 in a model for skin fibrosis (2020)
- Ozaki Y et al. Comprehensive Analysis of Chemotactic Factors for Bone Marrow Stem Cells (2007)
- Lynch SE et al. Injury induces expression of PDGF and PDGF receptors in skin cells and fibroblasts (1991)
Safety & Toxicology
Nonclinical and clinical safety
- Lynch SE, et al. A Review of the Safety of externally applied recombinant human platelet-derived growth factor (rh-PDGF-BB) for medical and cosmetic applications (2026)
- Lynch SE et al. Safety of up to 140 Daily Applications of Recombinant Human Platelet-Derived Growth Factor (rhPDGF-BB) Onto Skin Wounds (2025)
- Hee CK et al. Safety of rh-PDGF-BB in Augment® Bone Graft (2012)
- Young S, et al. Preclinical toxicology studies of rh-PDGF-BB alone or in combination with β-TCP and type I collagen (2010)
- Knight EV et al. A Review of Nonclinical Toxicology Studies of Topical rh-PDGF-BB Gel (1998)
- Solchaga LA et al. Effect of Implantation of Augment® Bone Graft on rh-PDGF-BB serum concentrations: A Pharmacokinetic study (2013)
- Smiell JM. Clinical safety of becaplermin (rhPDGF-BB) gel. Becaplermin Studies Group (1998)
Aesthetic Medicine
Cosmetic topical clinical evaluations
- Lynch SE et al. Recombinant Platelet-Derived Growth Factor (rh-PDGF-BB) in Tissue Repair and Rejuvenation (2026)
- Lynch SE et al. rh-PDGF-BB vs. Autologous Nanofat to Enhance Recovery After CO2 Laser and Microneedling: A Randomized Controlled Trial (2026)
- Lynch SE et al. Pure rh-PDGF-BB Improved Aesthetic Results and Patient Satisfaction Following RF Microneedling (2025)
- Gold MH, et al. Setting the Standard for Peer-Reviewed Published Studies on Regenerative Products in Aesthetic Medicine and Post-Procedure Wound Care. (2026)
- Lynch SE, et al. Clinical Applications of Pure Recombinant Platelet-Derived Growth Factor BB in Esthetic Medicine and Plastic Surgery. Facial Plast Surg (2026)
Wound Healing
Randomized, Controlled, Clinical Trials
- Smiell JM, et al. Efficacy and Safety of becaplermin (rh-PDGF-BB) in Patients with Nonhealing Diabetic Ulcers: Combined Analysis of Four randomized Studies (1999)
- Rees RS, et al. Becaplermin (rh-PDGF-BB) Gel in the Treatment of Pressure Ulcers: A Phase II Randomized, placebo-controlled study (1999)
- Wieman TJ. Clinical efficacy of becaplermin (rh-PDGF-BB) gel. (1998)
- Wieman TJ, et al. Efficacy and Safety of rh-PDGF-BB Topical Gel Formulation (Becaplermin) in Patients with Chronic Neuropathic Diabetic Ulcers (1998)
- Zhao Y, et al. Efficacy of Topical rh-PDGF-BB for Treatment of Diabetic Lower Extremity Ulcers (2014)
- Fang RC, et al. A Review of Becaplermin (rh-PDGF-BB) Gel in the Treatment of Diabetic Neuropathic Foot Ulcers (2008)
Oral & Peridontal Regeneration
Randomized, Controlled, Clinical Trials
- Lynch SE, et al. PDGF Stimulates Bone Fill and Connective Tissue Gain: Results of a Large Randomized Controlled Trial (2005)
- Meghil MM, et al. Histologic Evidence of Oral and Periodontal Regeneration Using rh-PDGF (2023)
- Tavelli L, et al. Rh-PDGF: A Systematic review of Clinical Findings in Oral Regenerative Procedures (2022)
- Lynch SE, et al. Periodontal Regeneration in Humans Using rh-PDGF-BB and Allogenic Bone (2003)
Orthopaedic & Bone Regeneration
Randomized, Controlled, Clinical Trials
- Lynch SE et al. rh-PDGF-BB and β-TCP: An Alternative to Autogenous Bone Graft (2013)
- Bertlet JT, et al. The Impact of Patient Age on Foot and Ankle Joint Fusion Supplemented with Autograft or Alternative (PDGF/ β-TCP) (2020)
- Loveland JD, et al. A Retrospective Case Series of Patients with Charcot Foot/Joint Deformity Undergoing Joint Fusion and Utilizing rh-PDGF with β-TCP (2021)
- Loveland JD, et al. Retrospective Review of rh-PDGF with β-TCP Bone Graft Substitute in Hindfoot/Ankle Joint Fusion (2023)